264 papers
This study demonstrates that rather than minimizing cellular heterogeneity, proper axial organization in gastruloids emerges from a division of labor among intrinsically biased stem cell clones, where the mixing of distinct anterior- and posterior-prone populations restores developmental precision that pure clones cannot achieve alone.
This study demonstrates that in zebrafish, the transcription factor MITF safeguards melanocyte stem cell fate during embryogenesis and is essential for adult regeneration, as its loss triggers premature progenitor expansion, the emergence of novel transcriptional states, and stage-specific defects in pigment cell lineages.
This study demonstrates that TET-dependent DNA demethylation is essential for retinal development by activating critical genes, and its inactivation causes global developmental disruption, leading to an abnormal expansion of cone cells, the emergence of defective cell types, and eventual blindness.
This study demonstrates that a mouse model of Kosaki overgrowth syndrome driven by a constitutively active PDGFRb mutation recapitulates human disease phenotypes and reveals that STAT1 signaling acts as a critical limiting factor that opposes PDGFRb-driven overgrowth and fibrosis.
This study identifies that dysregulation of the Hippo signaling pathway, driven by recurrent genetic variants, causes choroid plexus overgrowth and functional deficits in bipolar disorder, establishing the choroid plexus as a key developmental origin of the disease.
This paper presents a robust, label-free, high-content live-cell imaging pipeline that enables real-time, quantitative analysis of cell fusion dynamics by integrating automated image acquisition with texture-based segmentation and morphology metrics to distinguish true fusion events from clustering, thereby facilitating mechanistic studies and high-throughput screening of fusion modulators.
This study demonstrates that gestational exposure to low-level environmental chemical mixtures in an outbred sheep model induces widespread, sex-specific, and lineage-dependent epigenetic changes that persist intergenerationally but face challenges in distinguishing true transgenerational inheritance from genetically regulated methylation variation.
This study demonstrates that injury-induced Cxcl11 and neutrophil signaling drive zebrafish kidney regeneration by activating an innate immune response that establishes a nephrogenic niche characterized by coordinated Fgf and Wnt signaling, which is essential for activating stem cells and forming new functional nephrons.
By utilizing 3D imaging and genetic perturbations, this study reveals that the mouse placenta invades uterine spiral arteries more extensively than previously recognized and that disrupting early CXCL12-CXCR4 signaling leads to excessive trophoblast invasion mimicking human placenta accreta, thereby establishing the mouse as a superior model for studying balanced uteroplacental development.
This study reveals that cortex glia secrete the EGF antagonist Argos to locally inhibit ERK activity at the lateral margin of the Drosophila optic lobe neuroepithelium, thereby suppressing the proneural wave to instruct lamina precursor fate over medulla neuroblast fate.
This study develops a fluorescent dauer reporter in *Caenorhabditis inopinata* to enable comparative analysis, revealing that the molecular mechanisms governing dauer induction differ significantly between this species and the model organism *C. elegans*.
This study demonstrates that a flexible robotic platform integrated with machine learning can standardize and optimize the differentiation of human pluripotent stem cells into hematopoietic progenitor cells, significantly reducing experimental variability and uncovering superior culture conditions that are difficult to identify through conventional manual methods.
This study identifies the secreted protein BUG-1 as essential for forming stereotyped attachments between neuronal primary cilia and glial cells in *C. elegans*, demonstrating that these physical connections are critical for maintaining cilia morphology and regulating stimulus-evoked calcium signaling.
This study presents a comprehensive developmental single-cell atlas of Drosophila visual system glia, revealing how cell type diversity arises through distinct maturation trajectories and uncovering a novel mechanism of subcellular mRNA compartmentalization that distinguishes the transcriptomes of glial cell bodies from their processes.
Using an agent-based model, this study demonstrates that the ability of multicellular tissues to heal from injury is intrinsically linked to their morphological organization, specifically requiring large, contiguous cellular domains formed through developmental cell-fate decisions.
Using human induced pluripotent stem cell-derived retinal organoids, this study identifies a conserved wave of programmed retinal ganglion cell death occurring at week 8 of differentiation, which is mediated by the extrinsic apoptotic pathway via caspase 8 activation.
This study identifies the developmental regulator WT1 as a critical, isoform-tuned mechanism that drives lineage bias during the transition from naive to formative pluripotency by overriding naive networks and activating distinct anterior and posterior transcriptional programmes conserved across species.
This study reveals a self-reinforcing feedforward regulatory circuit between Adgrg6 and Sox9 that maintains extracellular matrix organization in spinal tissues, providing a mechanistic explanation for the genetic interaction underlying adolescent idiopathic scoliosis susceptibility.
This study demonstrates that the spatially precise cell fate decisions of cranial neural crest-derived cells in the developing zebrafish jaw are orchestrated by the triangulation of Bmp, Fgf, and Hedgehog signaling pathways, which converge on distinct gene regulatory modules to establish separate oral and aboral transcriptional domains.
By combining comparative functional genomics with mouse-bat sequence swaps, this study identifies specific regulatory elements that drive bat limb development, demonstrating how subtle genetic changes in enhancers collectively produce key flight-related phenotypes such as elongated digits and delayed ossification.